Dissecting how tubulin code controls microtubule properties

Project Summary:
The human genome encodes multiple α- and β-tubulin gene families (i.e., isotypes) with the protein expression profile varying with cell types and developmental stages. While point mutations in a specific tubulin isotype have been associated with human diseases, the molecular mechanism by which tubulin isotypes confer microtubules’ functions remains poorly understood. Using our field-leading strategy to generate isotypically pure recombinant human tubulin, Dr. Ti’s Lab employs combinatorial approaches of protein biochemistry, biophysics, chemical biology, single-molecule microscopy, force microscopy, and cryo-electron microscopy to investigate the intrinsic properties of different human tubulin isotypes (for more details, please visit http://www.tilab.org).

Deliverables:
A poster

Preferred discipline(s):
Chemistry, Biochemistry, and Physics

Project Essential Skills:
Lab work

Other Selection Criteria (if any):
N/A

Details of supervision arrangements:
Lab work will be essential. The student also needs to attend the weekly face-to-face group meeting.